Author

Laurent Guillaud

Okinawa Institute of Science and Technology Graduate UniversityORCID 0000-0002-9688-0991Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Organism:rat· 1

Frequent Co-Authors

Han-Ying WangiD· 1 shared Hiroshi Yamada· 1 shared Kohgaku EguchiiD· 1 shared Kohji TakeiiD· 1 shared Marco Edoardo RostiiD· 1 shared Marco TerenzioiD· 1 shared Maria Fransiska Emily· 1 shared Riya AgrawaliD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Han-Ying WangORCID

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2 papers

Recent·Most cited

Impairment in axonal translation and cytoplasmic viscosity during aging in sensory neurons

Maria Fransiska Emily, Laurent Guillaud, Sandra de la Fuente, Riya Agrawal, Susan Boerner, Yuto Akimoto, T Turkki, Marco Edoardo Rosti, Marco Terenzio

This study shows that aging reduces axonal translation in sensory neurons, linked to decreased mitochondrial activity and ATP levels, which can be partially reversed by increasing ATP synthesis.

bioRxiv · Jun 3, 2025 · PreprintNeuroscience

Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer's disease synapse model

Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi

The paper shows that soluble wild-type tau in presynaptic terminals causes microtubule assembly, which sequesters dynamin and impairs vesicle endocytosis and neurotransmission in an Alzheimer's disease model.

eLife · Apr 26, 2022Peer-reviewedNeuroscience