Author

Tomoyuki Takahashi

Okinawa Institute of Science and Technology Graduate UniversityORCID 0000-0002-8771-7666Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:electronic health records· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Organism:rat· 1

Frequent Co-Authors

Satyajit MahapatraiD· 2 shared Han-Ying WangiD· 1 shared Hiroshi Yamada· 1 shared Kohgaku EguchiiD· 1 shared Kohji TakeiiD· 1 shared Laurent GuillaudiD· 1 shared Tetsuya HoriiD· 1 shared Tomohiro MiyasakaiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Satyajit MahapatraORCID

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2 papers

Recent·Most cited

Physiological roles of endocytosis and presynaptic scaffold in vesicle replenishment at fast and slow central synapses

Satyajit Mahapatra, Tomoyuki Takahashi

The paper investigates the role of endocytosis and presynaptic scaffold proteins in vesicle replenishment at fast and slow central synapses, finding that endocytosis supports replenishment universally while the scaffold mechanism is specialized for fast synapses.

eLife · Nov 17, 2023Peer-reviewedNeuroscience

Microtubule assembly by soluble tau impairs vesicle endocytosis and excitatory neurotransmission via dynamin sequestration in Alzheimer's disease synapse model

Tetsuya Hori, Kohgaku Eguchi, Han-Ying Wang, Tomohiro Miyasaka, Laurent Guillaud, Zacharie Taoufiq, Satyajit Mahapatra, Hiroshi Yamada, Kohji Takei, Tomoyuki Takahashi

The paper shows that soluble wild-type tau in presynaptic terminals causes microtubule assembly, which sequesters dynamin and impairs vesicle endocytosis and neurotransmission in an Alzheimer's disease model.

eLife · Apr 26, 2022Peer-reviewedNeuroscience