Senescent tenocytes drive an age-associated loss of cell-extracellular matrix homeostasis, which can be partially restored using dihydroresveratrol
Jack Llewellyn, Nodoka Iwasaki, Anna Hoyle, Iolanda Vendrell, G. Berridge, K H Collins, Hollie Delo, Roger K.W. Smith, Jayesh Dudhia, Richard Faragher, Chavaunne T. Thorpe
This study shows that senescent tenocytes contribute to age-related tendon degeneration and that dihydroresveratrol can partially restore matrix homeostasis.
bioRxiv · Jul 27, 2026 · PreprintCell Biology