Anna Hoyle

This study shows that senescent tenocytes contribute to age-related tendon degeneration and that dihydroresveratrol can partially restore matrix homeostasis.

This study quantifies age-related changes in kidney extracellular matrix turnover and identifies structural and functional alterations linked to fibrosis.

The paper develops an in-silico pipeline to analyze degradomes from proteomic datasets, revealing disease- and endotype-specific tissue remodeling patterns in arthritis.

The paper identifies ThrEDs, a novel type of extracellular particle that accelerates wound healing and reduces fibrotic responses in patient-derived myofibroblasts.

The paper investigates collagen fibril formation in fibroblasts, showing it occurs at the plasma membrane independently of secretion and involves endocytosis.

This study shows that GMAP210 and Golgin-160 have distinct roles in maintaining Golgi structure, both necessary for efficient ECM secretion and modification.

The paper uses stable isotope labeling and mass spectrometry to show that tendon ECM has circadian and permanent pools with distinct turnover rates, which change with age.