Kelsey H. Collins

Leptin Drives Osteoarthritis Pain Through Sensory Neuron Reprogramming Independent of Cartilage Signaling

This study shows leptin drives OA pain via sensory neuron reprogramming, not cartilage signaling, by analyzing mouse models and human datasets.

Senescent tenocytes drive an age-associated loss of cell-extracellular matrix homeostasis, which can be partially restored using dihydroresveratrol

This study shows that senescent tenocytes contribute to age-related tendon degeneration and that dihydroresveratrol can partially restore matrix homeostasis.

Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis

The paper identifies an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, explaining pain-structure discordance in obesity-associated osteoarthritis.

Complement factor D (adipsin) mediates pressure-pain hypersensitivity post destabilization of medial meniscus injury

This study shows that absence of complement factor D increases pressure-pain hyperalgesia in mice after medial meniscus injury despite cartilage protection.

Chondrocyte-Specific Knockout of Piezo1 and Piezo2 Protects Against Post-Traumatic Osteoarthritis Structural Damage and Pain in Mice

This study shows that knocking out Piezo1 and Piezo2 in chondrocytes protects against post-traumatic osteoarthritis structural damage and pain in mice.

A Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery

This paper develops a bioartificial implant using CRISPR-Cas9-engineered stem cells to deliver anti-cytokine drugs in response to inflammation, reducing arthritis severity in mice.