Author

Hongyi Cai

Tsinghua University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:contrastive learning· 1 Assay:cryo-EM· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Bowen GaoiD· 1 shared Chuangye YaniD· 1 shared Haichuan Tan· 1 shared Huasong AiiD· 1 shared J. Tian· 1 shared Jiaxin Tan· 1 shared Jiqing ZhengiD· 1 shared Lei Liu· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioinformatics

Bowen GaoORCID

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2 papers

Recent·Most cited

Deep contrastive learning enables genome-wide virtual screening

Yinjun Jia, Bowen Gao, Jiaxin Tan, Jiqing Zheng, Xin Hong, Wenyu Zhu, Haichuan Tan, Yuan Xiao, Liping Tan, Hongyi Cai, Yanwen Huang, Zhiheng Deng, Xiangwei Wu, Yue Jin, Yafei Yuan, , Yanyan Lan

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

Science · Jan 8, 2026Peer-reviewedBioinformatics✦ In-depth digest

Steric Gating Dictates Selective Activation of BIRC6 by UBA6 Over UBA1

Zebin Tong, Rujing Yuan, Xiaoan Wu, Hongyi Cai, Xu Ziyu, Lei Liu, Huasong Ai

This study identifies steric compatibility between BIRC6 and UBA6 as the mechanism enabling specific activation of BIRC6 by UBA6 over UBA1.

bioRxiv · Dec 5, 2025 · PreprintBiochemistry