Author

Xiangwei Wu

Center for Life SciencesORCID 0009-0002-9367-8306Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xiangwei Wu1 paper · Shihezi University

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:contrastive learning· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

Bowen GaoiD· 1 shared Chuangye YaniD· 1 shared Haichuan Tan· 1 shared Hongyi Cai· 1 shared Huasong AiiD· 1 shared J. Tian· 1 shared Jiaxin Tan· 1 shared Jiqing ZhengiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBioinformatics

Bowen GaoORCID

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2 papers

Recent·Most cited

Deep contrastive learning enables genome-wide virtual screening

Yinjun Jia, Bowen Gao, Jiaxin Tan, Jiqing Zheng, Xin Hong, Wenyu Zhu, Haichuan Tan, Yuan Xiao, Liping Tan, Hongyi Cai, Yanwen Huang, Zhiheng Deng, Xiangwei Wu, Yue Jin, Yafei Yuan, , Yanyan Lan

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

Science · Jan 8, 2026Peer-reviewedBioinformatics✦ In-depth digest

Mechanistic Insights into the Stimulation of the Histone H3K9 Methyltransferase Clr4 by Proximal H3K14 Ubiquitination

Yunxiang Du, Maoshen Sun, Zhengqing Li, Xiangwei Wu, Qian Qu, Huasong Ai, Lei Liu

The paper determines the crystal structures of Clr4 bound to ubiquitinated and unmodified H3 peptides, revealing how H3K14 ubiquitination synergistically enhances Clr4 catalytic activity through conformational changes and multivalent interactions.

Science Advances · May 30, 2025Peer-reviewedMolecular Biology