Chuangye Yan

The paper characterizes five new glycofibrils isolated from Tsinghua Lotus Pond using cryo-EM and AI, revealing structural diversity in their central protein components and glycans.

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

This paper identifies atazanavir as a pan-positive allosteric modulator that activates multiple Family A GPCRs and sustains G protein signaling through non-canonical mechanisms.

This study determines the structure of a GPCR-G protein-β-arrestin complex stabilized by an allosteric modulator, showing a novel binding mode that allows coexistence with G protein signaling.

The paper reports a cryo-EM structure of Chlamydomonas mastigoneme, revealing a 5',5'-phosphodiester bond stabilizing glycan folding.

This study identifies a Ca2+ sensor/TIR-only node that links PRR signaling to NLRs by repressing and de-repressing STIR1 function, enabling ADR1 recognition of pRib-AMP-EDS1-PAD4 for stomatal immunity.