Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons
Emily R. Lowry, Tulsi Patel, Jonathon A. Costa, Elizabeth Chang, Shahroz Tariq, Hranush Melikyan, Ian J. Davis, Siaresh Aziz, Georgia Ntermentzaki, Francesco Lotti, Hynek Wichterle
This study re-expresses embryonic motor neuron factors in mature neurons to reverse age-related degeneration and reduce ALS symptoms in a mouse model.
Nature Neuroscience · Aug 12, 2025Peer-reviewedNeuroscience