Francesco Lotti

This study re-expresses embryonic motor neuron factors in mature neurons to reverse age-related degeneration and reduce ALS symptoms in a mouse model.

The paper improves the synthesis of C15AlkOPP and uses it to label and analyze prenylated proteins in motor neurons, astrocytes, and their stem cell progenitors, identifying 54, 50, and 84 prenylated proteins respectively.

This study shows that Stasimon overexpression in SMA mice improves motor function by preventing synaptic loss and motor neuron death through mechanisms involving p53 regulation.