Tulsi Patel

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability

The paper identifies a neuron type-specific microexon in Ank3/ankyrin-G that modulates calcium activity and neuronal excitability through alternative splicing.

From Wiring to Firing: Collapse of embryonic identities and emergence of functional diversity during motor neuron maturation

This study tracks the transcriptional and chromatin changes in mouse motor neurons during maturation, revealing dynamic shifts in diversity and functional identity.

Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons

This study re-expresses embryonic motor neuron factors in mature neurons to reverse age-related degeneration and reduce ALS symptoms in a mouse model.

General and cell-type-specific aspects of the motor neuron maturation transcriptional program

The paper maps gene expression and chromatin accessibility changes in mouse spinal motor neurons during maturation, revealing dynamic regulatory elements and shared transcription factor motifs.

Ranking Reprogramming Factors for Directed Differentiation

The paper evaluates nine computational methods for identifying and ranking reprogramming factors in directed differentiation, finding that chromatin accessibility-based methods like DeepAccess and AME perform best.