Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis
Weilun Guo, Shruti Apte, Mary S Dickinson, So Young Kim, Miriam Kutsch, Jörn Coers
This study identifies GVIN1 as an IFNg-inducible host defense protein that blocks Burkholderia thailandensis from using actin polymerization for motility by forming a coatomer that displaces BimA.
bioRxiv · Mar 24, 2025 · PreprintImmunology