Author

Huihui Dai

SUNY Upstate Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1

Frequent Co-Authors

Wei‐Dong YaoiD· 4 shared Hannah L. PhillipsiD· 2 shared Hongyu RuaniD· 2 shared Alexis S. Zajicek· 1 shared Aparajita Baral· 1 shared Aya M. KobeissiiD· 1 shared Behnam JavidfariD· 1 shared Fen‐Biao GaoiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersNeuroscience

Wei‐Dong YaoORCID

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4 papers

Recent·Most cited

A Prefrontal Cortex-Nucleus Accumbens Circuit Attenuates Cocaine-conditioned Place Preference Memories

Xiaobo Wu, Aya M. Kobeissi, Wen-Yong You, Hannah L. Phillips, Huihui Dai, Yong‐Jing Gao, Wei‐Dong Yao

This study shows that IL-NAcSh neurons suppress cocaine-associated memories through reduced excitability after cocaine exposure, and restoring their activity can extinguish these memories.

Molecular Psychiatry · Apr 4, 2026Peer-reviewedNeuroscience

Elevating Neuronal CYLD Causes Frontotemporal Dementia (FTD)-Relevant Behavioral and Physiological Deficits

Aparajita Baral, Mohammad Bilal, Huihui Dai, Yong‐Woo Jun, Sandra Almeida, Fen‐Biao Gao, Wei-Dong Yao

This study shows that elevating neuronal CYLD causes FTD-like behavioral and physiological deficits in mice, with M719V mutation acting as a gain-of-function.

bioRxiv · Feb 26, 2026 · PreprintNeuroscience

USP48/USP31 Is a Nuclear Deubiquitinase that Potently Regulates Synapse Remodeling

Qi Ma, Hongyu Ruan, Huihui Dai, Wei‐Dong Yao

This study identifies USP48 as a nuclear deubiquitinase that regulates synapse remodeling by promoting spine pruning and reducing synaptic protein clustering.

bioRxiv · Sep 19, 2023 · PreprintNeuroscience

Cylindromatosis Drives Synapse Pruning and Weakening by Promoting Macroautophagy through Akt-mTOR Signaling

Alexis S. Zajicek, Hongyu Ruan, Huihui Dai, Mary Catherine Skolfield, Hannah L. Phillips, Wendi J. Burnette, Behnam Javidfar, Shao‐Cong Sun, Schahram Akbarian, Wei‐Dong Yao

This study shows CYLD promotes synapse pruning and weakening via Akt-mTOR-autophagy signaling, leading to behavioral and synaptic deficits in mice.

Molecular Psychiatry · Apr 21, 2022Peer-reviewedNeuroscience