Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior
Xiao Yu, Wei Ba, Guangchao Zhao, Ying Ma, Edward C. Harding, Lu Yin, Dan Wang, Huiming Li, Peng Zhang, Youran Shi, Raquel Yustos, Alexei L. Vyssotski, Hailong Dong, Nicholas P. Franks, William Wisden
This study shows that dysfunction of VTA GABA neurons leads to mania-like behaviors, including increased wakefulness and reduced sleep, which can be reversed by valproate.
Molecular Psychiatry · Jun 17, 2020Peer-reviewedNeuroscience