Dlx2 reprograms the transcriptome and laminar position of glia-derivedAscl1-induced interneurons
Alexis Cooper, Araceli Garcia-Mora, G. Herrera-Oropeza, Ana Beltrán-Arranz, Nicolás Marichal, Youran Shi, Sydney Leaman, Karla Lozano Gonzalez, Molly Strom, Fursham Hamid, François Guillemot, Benedikt Berninger
This study shows that a modified Ascl1 variant, Ascl1SA6, can reprogram glial cells into interneurons that resemble canonical cortical interneurons when combined with Dlx2, improving their laminar positioning.
bioRxiv · Jan 2, 2026 · PreprintNeuroscience