Locus Coeruleus Norepinephrine Neurons Facilitate Orbitofrontal Cortex Remapping and Behavioral Flexibility
M. Cameron Ogg, Benjamin Lansdell, Hunter T. Franks, Alex C. Hughes, Jimin Lee, Hunter G. Nolen, Abbas Shirinifard, Lindsay A. Schwarz
This study shows that locus coeruleus norepinephrine neurons regulate orbitofrontal cortex cognitive map stability and behavioral flexibility through bidirectional signaling.
Cell Reports · Dec 1, 2025Peer-reviewedNeuroscience