Abbas Shirinifard

ExpertTwins: Auditable Long Horizon Scientific Panels through Grounded Expertise

ExpertTwins is a framework for auditable scientific deliberation using evidence-based roles, showing high quotation grounding and differentiated reasoning across models and tasks.

Crop-OCT: a Fully Integrated Imageomics Pipeline to Identify Regional and Focal Retinopathy in Murine Models

Crop-OCT is an automated pipeline for analyzing OCT images to identify retinopathy in murine models, enabling the detection of regional and focal lesions across multiple diseases.

Locus Coeruleus Norepinephrine Neurons Facilitate Orbitofrontal Cortex Remapping and Behavioral Flexibility

This study shows that locus coeruleus norepinephrine neurons regulate orbitofrontal cortex cognitive map stability and behavioral flexibility through bidirectional signaling.

Canonical Hedgehog Signaling Controls Astral Microtubules and Mitotic Spindle Orientation in Neural Progenitors and iPSCs

This study shows that Hedgehog signaling regulates mitotic spindle orientation in neural progenitors and iPSCs by affecting astral microtubules and transcriptional regulation of microtubule dynamics.

Latent Epigenetic Programs in Muller Glia Contribute to Stress, Injury, and Disease Response in the Retina

The paper identifies 'pliancy genes' in Muller glia that enable rapid response to retinal stress, injury, and disease, showing species-specific differences in their activation between zebrafish and mammals.

Junctional Adhesion Molecule (JAM)-C recruitment of Pard3 and drebrin to cell contacts initiates neuron-glia recognition and layer-specific cell sorting in developing cerebella.

This study shows that JAM-C on cerebellar granule neurons interacts with glial cells to recruit Pard3 and drebrin, enabling cell sorting and layer-specific positioning during cerebellar development.

Phosphorylation of 53BP1 by ATM enforce neurodevelopmental programs in cortical organoids

This study shows that ATM-mediated phosphorylation of 53BP1-serine 25 is essential for neural progenitor cell proliferation and neuronal differentiation in cortical organoids.