Alex C. Hughes

This study shows that cell type-specific AADC expression in Parkinson's disease models reduces motor deficits and dyskinesia more effectively than broad targeting.

This study shows that locus coeruleus norepinephrine neurons regulate orbitofrontal cortex cognitive map stability and behavioral flexibility through bidirectional signaling.

The paper introduces ConVERGD, a single-construct intersectional AAV strategy for targeting specific cell populations, and demonstrates its use in targeting NE+ LC neurons expressing Pdyn in rodents.