Author

Cassandra Herbert

University of Cincinnati

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Patrick A. LimbachiD· 4 shared Amirtha ShekariD· 1 shared Andrew HolmesiD· 1 shared Andrew Palacios· 1 shared Arturo Ledezma Ramírez· 1 shared Arundhati KavooriD· 1 shared Catherine DenicourtiD· 1 shared Chathuri PathirageiD· 1 shared

Activity by Year

2025-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersGenomics

Patrick A. LimbachORCID

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Author profile →

4 papers

Recent·Most cited

A survey of dietary effects on tRNA abundance and modifications

Simeiyun Liu, Andrew Holmes, Ruoxia Zhao, Cassandra Herbert, Patrick A. Limbach, Todd M. Lowe, Upasna Sharma

This study examines how low-protein and high-fat diets affect tRNA abundance and modifications in multiple mouse tissues using RNA mass spectrometry and OTTR-seq.

bioRxiv · Jun 10, 2025 · PreprintGenomics

A microbiome-derived nutrient underlies tyrosine metabolism and predator avoidance in mosquito larvae

Melissa Kelley, Shubham Rathore, Karthikeyan Chandrasegaran, Cassandra Herbert, Chloe Elizabeth G. Sabile, Taylor Wood, Judd Joves, Andrew Palacios, Emily E. Susanto, Melissa R. Uhran, Arturo Ledezma Ramírez, Shyh‐Chi Chen, Joshua Tompkin, Khwahish Singh, Muhmmad S. Khalid, , Joshua B. Benoit

This study shows that microbiome-derived queuosine (Q) affects tyrosine metabolism and predator avoidance in mosquito larvae, leading to impaired behavior and survival.

bioRxiv · Apr 2, 2025 · PreprintPhysiology

Structural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase

Swapnil C. Devarkar, Christina R. Budding, Chathuri Pathirage, Arundhati Kavoor, Cassandra Herbert, Patrick A. Limbach, Karin Musier‐Forsyth, Yong Xiong

This study reveals the structural mechanism of human lysyl-tRNA synthetase aminoacylation of modified tRNALys3 using cryo-EM structures.

Nucleic Acids Research · Feb 27, 2025Peer-reviewedBiochemistry

TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress.

Sseu-Pei Hwang, Han Liao, Katherine Barondeau, Xinyi Han, Cassandra Herbert, Hunter McConie, Amirtha Shekar, Dimitri G. Pestov, Patrick A. Limbach, Jeffrey T. Chang, Catherine Denicourt

This study identifies TRMT1L as the methyltransferase responsible for m22G27 modification on tRNA-Tyr-GUA, showing its role in translation efficiency and oxidative stress resistance.

Cell Reports · Jan 1, 2025Peer-reviewedMolecular Biology