Cell heterogeneity contributes to the variable response of HIV-1 to latency reversing agents
Rachel Topno, Hussein Karaki, Flavia Mazzarda, Oriane Pourcelot, Manon Philippe, Kazem Zibara, Ovidiu Radulescu, Édouard Bertrand
The paper investigates HIV-1 transcription variability using a dual-copy MS2-tagging system and mathematical analysis, finding that cellular heterogeneity influences the response to latency-reversing agents.
Science Advances · Oct 9, 2026Peer-reviewedMolecular Biology