Mounia Lagha

The paper shows that muscle progenitors decode Notch signaling levels through transcriptional burst duration, with higher Delta levels leading to stronger Notch signaling and distinct transcriptional outputs.

The paper investigates how Snail-mediated repression coordinates cell fate decisions through transcription factor cooperativity and multiple inactive promoter states during development.

The paper investigates how nuclei respond to mechanical forces during EMT using Drosophila mesoderm invagination, showing spatially distinct transcriptional responses.

The paper uses optogenetics to manipulate Dorsal levels in Drosophila embryos, revealing a critical temporal window for its function in patterning and transcriptional regulation.

The paper discusses imaging methods to visualize and quantify translation dynamics in early Drosophila embryos using a twist-32XSunTag reporter and provides a protocol for live imaging and fixed sample analysis.

This study examines the spatiotemporal dynamics of bcd mRNA translation in Drosophila oocytes and embryos, revealing that translation is restricted to the anterior pole and regulated by P bodies.

The paper improves fluorescent tools for live imaging of translation in Drosophila embryos and mammalian cells, introducing new methods like ALFA-array and MCP-tdStaygold.

This study shows that the transcription factor GAF acts as a stable mitotic bookmark during zygotic genome activation in Drosophila embryos, enabling rapid transcriptional activation after mitosis.

The paper uses live imaging and computational methods to study how promoter motifs affect transcriptional bursting in Drosophila embryos, revealing distinct dynamics for TATA and INR motifs.

The paper uses Suntag to image mRNA translation in Drosophila embryos, revealing spatial heterogeneity and translation factories.

The paper uses Hi-M to study cis-regulatory loops in Drosophila development, showing they form before TADs and gene activation, and are independent of cell fate.

The paper investigates how the pioneer factor Zelda controls gene expression timing through transient chromatin interactions in Drosophila embryos.