The paper investigates HIV-1 transcription variability using a dual-copy MS2-tagging system and mathematical analysis, finding that cellular heterogeneity influences the response to latency-reversing agents.

Science Advances · Oct 9, 2026Peer-reviewedMolecular Biology

Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics

Věra Slaninová, Flavia Mazzarda, Lasha Dalakishvili, David Depierre, Christina J. I. Moene, Rachel Topno, Jean‐Marc Escudier, Marie-Cécile Robert, Olivier Cuvier, Arnaud Regis Krebs, Nacho Molina, Ovidiu Radulescu, Édouard Bertrand

The paper uses SMF and live imaging to study promoter dynamics, showing Tat influences nucleosome removal and polymerase activity.

bioRxiv · Nov 26, 2025 · PreprintMolecular Biology

Boosting the toolbox for live imaging of translation

Maëlle Bellec, Ruoyu Chen, Jana Dhayni, Antonello Trullo, Damien Avinens, Hussein Karaki, Flavia Mazzarda, Hélène Lenden Hasse, Cyril Favard, Ruth Lehmann, Édouard Bertrand, Mounia Lagha, Jérémy Dufourt

The paper improves fluorescent tools for live imaging of translation in Drosophila embryos and mammalian cells, introducing new methods like ALFA-array and MCP-tdStaygold.

RNA · Jul 26, 2024Peer-reviewedDevelopmental Biology