Ruth Lehmann

The paper identifies Sfxn1-3's role in regulating mitochondrial volume during the egg-to-embryo transition by controlling amino acid export and osmotic balance.

The paper shows that Drosophila germ cells maintain totipotency by transcribing an embryo-like program but repressing its translation through Nanos.

The paper shows that GCL pruning of PIP3 regulates the soma-germline boundary by modulating Torso-dependent PI3K activity and Myosin II constriction in Drosophila embryos.

This study uses synthetic biology to reconstitute germ granules and identifies Vasa/DDX4 as essential for RNA localization and translational activation.

The paper improves fluorescent tools for live imaging of translation in Drosophila embryos and mammalian cells, introducing new methods like ALFA-array and MCP-tdStaygold.

The paper shows that Integrator complex depletion disrupts histone gene expression timing by dispersing transcription machinery clusters.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

This study shows juvenile hormones (JHs) are necessary and sufficient for primordial germ cell (PGC) migration in Drosophila, with similar roles observed for retinoic acids in mammals.

The paper identifies a hormonal mechanism that coordinates primordial germ cell differentiation with somatic tissue morphogenesis in Drosophila ovaries.

The paper uses single-cell RNA sequencing to identify 34 cell types and subtypes in Drosophila ovaries, revealing unexpected diversity in escort cells and follicle cells.

This study uses single-cell RNA sequencing to identify novel cell types and lineage markers in the developing Drosophila ovary.

This study shows that L(3)mbt maintains tissue identity in Drosophila ovaries by preventing misexpression of germline-specific genes in somatic cells.