Rachel Topno

Cell heterogeneity contributes to the variable response of HIV-1 to latency reversing agents

The paper investigates HIV-1 transcription variability using a dual-copy MS2-tagging system and mathematical analysis, finding that cellular heterogeneity influences the response to latency-reversing agents.

Single-Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter Dynamics

The paper uses SMF and live imaging to study promoter dynamics, showing Tat influences nucleosome removal and polymerase activity.

Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

The paper uses single molecule imaging to study HIV-1 promoter pausing and finds that stochastic pausing leads to transcriptional bursting in latent cells.