In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Edward P. Harvey, Jeffrey S. Smith, Joseph D. Hurley, Alyana J. Granados, Ernst W. Schmid, Jason G. Liang-Lin, Huyang Zhang, Emily M. Meara, Elizabeth K. Wren, Steffanie Paul, Matthew P. Ferguson, Victor G. Calvillo-Miranda, Miguel A. Alcantar, Debora S. Marks, Johannes C. Walter, , Katherine J. Susa
The paper uses AlphaFold-Multimer to predict nanobody binders to MRGPRX2, demonstrating in silico antibody discovery for a GPCR target.
Nature Communications · Apr 23, 2026Peer-reviewedBiochemistry