Author

Joseph D. Hurley

Harvard UniversityORCID 0000-0002-3903-318XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Andrew C. KruseiD· 2 shared Alyana J. GranadosiD· 1 shared Debora S. MarksiD· 1 shared Edward P. HarveyiD· 1 shared Elizabeth K. Wren· 1 shared Emily M. MearaiD· 1 shared Eric S. FischeriD· 1 shared Ernst W. SchmidiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Andrew C. KruseORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedApr 23, 2026

In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer

Edward P. Harvey, Jeffrey S. Smith, Joseph D. Hurley…·Katherine J. Susa

The paper uses AlphaFold-Multimer to predict nanobody binders to MRGPRX2, demonstrating in silico antibody discovery for a GPCR target.

7 citationstop 1%

humanprotein structure

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BioengineeringACS Chemical BiologyPeer-reviewedAug 13, 2025

Decoding protein-peptide interactions using a large, target-agnostic yeast surface display library

Joseph D. Hurley, Irina Shlosman, Megha Lakshminarayan…·Andrew C. Kruse

The paper develops a large yeast surface display library to identify high-affinity peptide ligands for various protein targets, revealing binding motifs and novel clones.

4 citations

yeastproteomics

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