Author
Brigham and Women's HospitalORCID 0000-0003-2840-2899Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Claudia Y. Lee, Jeffrey S. Smith, Taylor Kohlmann…·Sudarshan Rajagopal
This study shows that G proteins and β-arrestins can directly interact, with Gi family members differing in their association with β-arrestin, and this selectivity is located in the alpha helical domain of Gi.
Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon…·Robert J. Lefkowitz
This study identifies small-molecule inhibitors of beta-arrestins and elucidates their mechanism, offering a framework for modulating GPCR signaling.
James Osei‐Owusu, Tristan Girbau, Xunan Wang…·Andrew C. Kruse
This study presents cryo-EM structures of RXFP1 bound to relaxin-2 and AZD5462, revealing distinct activation mechanisms for protein and small-molecule agonists.
Edward P. Harvey, Jeffrey S. Smith, Joseph D. Hurley…·Katherine J. Susa
The paper uses AlphaFold-Multimer to predict nanobody binders to MRGPRX2, demonstrating in silico antibody discovery for a GPCR target.