Ernst W. Schmid

The paper develops GolgiFold, a structure-based PPI map of human Golgi proteins, identifying over 1,800 interactions and confirming new protein contacts through experimental validation.

The paper uses AlphaFold-Multimer to predict nanobody binders to MRGPRX2, demonstrating in silico antibody discovery for a GPCR target.

This study identifies IWS1 as a modular scaffold that organizes the transcription elongation complex through its disordered region, revealing its role in recruitment and stimulation of elongation.

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

The paper develops a computational pipeline to predict human protein-protein interactions, identifying 16,000 high-confidence interactions, many previously unknown or structurally unresolved.

This study shows that USP37 prevents premature TRAIP-mediated disassembly of stalled replisomes, maintaining genome stability under replication stress.

The paper creates a structural interactome of human endosomes using cross-linking, mass spectrometry, and AlphaFold, identifying structural models for endosomal protein complexes.

This study identifies PBP1b's specialized role in E. coli division site fortification against osmotic rupture, showing it functions independently of LpoB and requires an extended N-terminus for recruitment by FtsA.

The paper introduces SPOC, a classifier to improve AlphaFold-Multimer predictions of protein-protein interactions, and curates a database of predicted interactions for human genome maintenance proteins.

The paper investigates the role of STK19 in transcription-coupled DNA repair by showing it positions TFIIH for repair in a cell-free system.

The paper uses AlphaFold-Multimer to screen human proteins for nucleosome acidic patch binding, identifies SHPRH as a novel binder, and determines its structure.