Author

Alyana J. Granados

University of California, San FranciscoORCID 0009-0006-1409-2382Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Katherine J. SusaiD· 2 shared Andrew C. KruseiD· 1 shared Debora S. MarksiD· 1 shared Edward P. HarveyiD· 1 shared Elizabeth K. Wren· 1 shared Emily M. MearaiD· 1 shared Ernst W. SchmidiD· 1 shared Huyang Zhang· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Katherine J. SusaORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedApr 23, 2026

In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer

Edward P. Harvey, Jeffrey S. Smith, Joseph D. Hurley…·Katherine J. Susa

The paper uses AlphaFold-Multimer to predict nanobody binders to MRGPRX2, demonstrating in silico antibody discovery for a GPCR target.

7 citationstop 1%

humanprotein structure

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BiochemistrybioRxivPreprintSep 25, 2025

Structural basis for regulation of Frizzled-4 signaling by the co-receptor Tetraspanin-12

Alyana J. Granados, Payal P. Pratap, Kevin Alexander Estrada Alamo, Katherine J. Susa

This paper reports the structure of the FZD4-Tspan12 complex and shows how Tspan12 enhances Norrin signaling by facilitating trafficking and higher-affinity Norrin binding.

DOI 10.1101/2025.09.25.678640

structural biologyexperimental assay

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