Preserved suppressive function despite loss of Foxp3: insights into the identity of regulatory T cells
Bianca Luckerbauer, Alejandro V. Villarino, Arian D. J. Laurence, Kiyoshi Hirahara, Giuseppe Sciumè, Yohei Mikami, HY Shih, Hong‐Wei Sun, Anela Tosevska, M Brinkmann, SR Brooks, Jörg Scheffel, Françoise Meylan, Behdad Afzali, Michael Markus Bonelli
This study shows that regulatory T cells can maintain suppressive function and a Treg signature even when Foxp3 expression is lost in Th2-driven disease models.
bioRxiv · Jan 17, 2025 · PreprintImmunology