Author

Behdad Afzali

National Institutes of HealthORCID 0000-0003-2968-1156Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2

Frequent Co-Authors

Alejandro V. VillarinoiD· 2 shared Dhaneshwar KumariD· 2 shared Anela TosevskaiD· 1 shared Anthony C. CruziD· 1 shared Arian D. J. LaurenceiD· 1 shared Bianca Luckerbauer· 1 shared Claudia KemperiD· 1 shared Daniel Chauss· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

Alejandro V. VillarinoORCID

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4 papers

Recent·Most cited

ImmunologybioRxivPreprintOct 11, 2026

Intracellular complement Factor B couples inflammatory sensing to metabolism, chromatin regulation and maladaptive tissue repair

Tilo Freiwald, Daniel Chauss, Md Tajmul…·Behdad Afzali

The paper identifies an injury-induced complement program in kidney cells that couples inflammation to metabolism and chromatin regulation, promoting maladaptive fibrosis.

DOI 10.64898/2026.10.04.756581

humanbulk RNA-seq

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ImmunologyThe Journal of Experimental MedicinePeer-reviewedJan 17, 2026

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling

Dominic P. Golec, Pedro Henrique Gazzinelli-Guimarães, Daniel Chauss…·Pamela L. Schwartzberg

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

1 citation

mousebulk RNA-seq

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GenomicsNature CommunicationsPeer-reviewedSep 25, 2025

Super-silencers are crucial for development and carcinogenesis in B cells.

Di Huang, Hanna M. Petrykowska, Dhaneshwar Kumar…·Ivan Ovcharenko

The paper identifies super-silencers in B cells, showing their role in development and their conversion to super-enhancers in lymphoma, with implications for carcinogenesis.

3 citations

humanChIP-seq

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ImmunologybioRxivPreprintJan 17, 2025

Preserved suppressive function despite loss of Foxp3: insights into the identity of regulatory T cells

Bianca Luckerbauer, Alejandro V. Villarino, Arian D. J. Laurence…·Michael Markus Bonelli

This study shows that regulatory T cells can maintain suppressive function and a Treg signature even when Foxp3 expression is lost in Th2-driven disease models.

1 citation

mousebulk RNA-seq

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