Critical role for astrocyte NAD+ glycohydrolase in myelin injury and regeneration
Monica Renee Langley, Chan‐Il Choi, Thais Peclat, Yong Guo, Whitney L. Simon, Hyesook Yoon, Laurel S. Kleppe, Claudia Francesca Lucchinetti, Claudia C.S. Chini, Eduardo N. Chini, Isobel A. Scarisbrick
This study shows that CD38 in astrocytes mediates NAD+ depletion and myelin damage caused by high fat diets and demyelination, with CD38 inhibitors improving myelin regeneration.
Journal of Neuroscience · Sep 7, 2021Peer-reviewedNeuroscience