Integrin-deficient T cell leukemia accumulates in the central nervous system
Samantha Y. Lux, Cynthia Chen, Bibi S. Subhan, Hyunsoo Chung, Martyna Okuniewska, Asha Y. Caslin, Kathleen A. Martin, Jennifer K. Schiavo, Jonah B. Vernejoul, Robert C. Froemke, Michael Cammer, Susan R. Schwab
This study shows that integrin-deficient T-cell leukemia accumulates in the CNS and proliferates faster, suggesting integrins normally restrict T-ALL growth there, and integrin blockade could enhance chemotherapy.
bioRxiv · Jun 28, 2024 · PreprintImmunology