Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium
G. R. Nahass, Y. Sun, Y. Xu, M. Batchelor, M. Reilly, I. Benilova, N. Kedia, K. Spehar, F. Sobott, R. B. Sessions, B. Caughey, S. E. Radford, P. Jat, J. Collinge, J. Bieschke
This paper shows Brazilin inhibits alpha-synuclein fibril formation and reduces toxicity in Parkinson's disease by altering conformational equilibrium.
bioRxiv · Sep 29, 2020Biochemistry