Author

I. Brun-Heath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Banuelos· 1 shared A. Escobedo· 1 shared A. Riera· 1 shared A. Ruffoni· 1 shared B. Mateos· 1 shared C. Batlle· 1 shared C. Garcia-Cabau· 1 shared C. Gonzalez· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. Banuelos

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Rational optimization of a transcription factor activation domain inhibitor

S. Basu, P. Martinez-Cristobal, M. Pesarrodona, M. Frigole-Vivas, E. Szulc, M. Lewis, A. Banuelos, C. Sanchez-Zarzalejo, S. Bielskute, J. Zhu, K. Pombo-Garcia, C. Garcia-Cabau, C. Batlle, B. Mateos, M. Biesaga, , X. Salvatella

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

bioRxiv · Aug 18, 2022Biochemistry

THE IMPACT OF THE HYDROXYMETHYLCYTOSINE EPIGENETIC SIGNATURE ON DNA STRUCTURE AND FUNCTION

F. Battistini, P. Dans, M. Terrazas, C. L. Castellazzi, G. Portella, M. Labrador, N. Villegas, I. Brun-Heath, C. Gonzalez, M. Orozco

This study investigates how 5-hydroxymethylation of DNA affects DNA structure and function, showing that hmC leads to more rigid DNA and alters MBD binding compared to mC.

bioRxiv · Sep 17, 2020 · PreprintBiochemistry