Author

K. Pombo-Garcia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Honigmann· 3 shared C. Martin-Lemaitre· 2 shared A. A. Hyman· 1 shared A. Banuelos· 1 shared A. Escobedo· 1 shared A. Riera· 1 shared A. Rizuan· 1 shared A. Ruffoni· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

A. Honigmann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

X. Yan, D. Kuster, P. Mohanty, J. Nijssen, K. Pombo-Garcia, A. Rizuan, T. M. Franzmann, A. Sergeeva, P. M. dos Passos, L. George, S.-H. Wang, J. Shenoy, H. L. Danielson, A. Honigmann, Y. M. Ayala, , A. A. Hyman

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

bioRxiv · Jan 23, 2024Cell Biology

Wetting of junctional condensates along the apical interface promotes tight junction belt formation

K. Pombo-Garcia, C. Martin-Lemaitre, A. Honigmann

The paper shows that PATJ-mediated wetting of junctional condensates at the apical membrane drives the formation of tight junction belts.

bioRxiv · Dec 16, 2022 · PreprintCell Biology

Rational optimization of a transcription factor activation domain inhibitor

S. Basu, P. Martinez-Cristobal, M. Pesarrodona, M. Frigole-Vivas, E. Szulc, M. Lewis, A. Banuelos, C. Sanchez-Zarzalejo, S. Bielskute, J. Zhu, K. Pombo-Garcia, C. Garcia-Cabau, C. Batlle, B. Mateos, M. Biesaga, , X. Salvatella

This study optimizes a small molecule inhibitor targeting the aromatic-rich activation domain of the androgen receptor, showing improved affinity and antitumorigenic effects in prostate cancer models.

bioRxiv · Aug 18, 2022Biochemistry

Phase separation of zonula occludens proteins drives formation of tight junctions

O. Beutel, R. Maraspini, K. Pombo-Garcia, C. Martin-Lemaitre, A. Honigmann

This study shows ZO proteins undergo phase separation to form tight junctions by creating membrane-bound compartments that organize junction components.

bioRxiv · Mar 26, 2019Cell Biology