C. Gonzalez

Podoplanin Positive Cell-derived Extracellular Vesicles Contribute to Cardiac Amyloidosis After Myocardial Infarction

This study identifies that Podoplanin-expressing mesenchymal stromal cells release exosomes that trigger SAA3 overproduction in macrophages, leading to cardiac amyloidosis after myocardial infarction.

The Drosophila cancer-germline, head-to-head gene pair TrxT and dhd is dispensable for normal brain development but plays a major role in l(3)malignant brain tumour growth.

Metabolomic rearrangement controls the intrinsic microbial response to temperature changes

The paper shows that metabolomic rearrangements, not stress responses, control bacterial temperature adaptation, with a model explaining growth dynamics under temperature shifts.

Mucins shed from the laminated layer in cystic echinococcosis are captured by Kupffer cells via the lectin receptor Clec4F

The paper shows that mucins from the laminated layer of E. granulosus are captured by Kupffer cells via Clec4F, highlighting a mechanism for host clearance of parasite-derived materials.

Deadly and venomous Lonomia caterpillars are more than the two usual suspects

The paper reevaluates the taxonomy and venom risks of Lonomia caterpillars, identifying 60 species and seven potentially dangerous ones, urging further research on venom diversity and treatment strategies.

Optimization and validation of a Protein Phosphatase inhibition assay for accessible microcystin detection.

The paper optimizes and validates a phosphatase inhibition assay for microcystin detection, showing high recovery, low LOD, and strong correlation with ELISA.

Cell-free synthesis and reconstitution of Bax in nanodiscs: comparison between wild-type Bax and a constitutively active mutant

The paper compares the reconstitution of wild-type Bax and a constitutively active mutant in nanodiscs, showing that BaxP168A forms larger nanodiscs indicative of active oligomerization.

Autophagy modulates apical growth and development in the moss Physcomitrium patens

This study shows autophagy modulates apical growth and development in moss protonemal cells, with differential effects on cell types and life cycle progression.

High genetic diversity in the pelagic deep-sea fauna of the Atacama Trench revealed by environmental DNA

This study uses environmental DNA to reveal high genetic diversity in the deep-sea fauna of the Atacama Trench, showing that deep waters contribute significantly to overall diversity.

Electroencephalographic Signatures of Canine Cognitive Dysfunction

This study identifies EEG biomarkers for canine cognitive dysfunction (CCD) and its early stages, showing differences in coherence and complexity between healthy, at-risk, and CCD-affected dogs.

Freshwater dissolved oxygen dynamics: changes due to glyphosate, 2,4-D and their mixture, both under clear and turbid-organic conditions.

This study examines how glyphosate, 2,4-D, and their mixture affect dissolved oxygen levels in freshwater under clear and turbid conditions, showing changes in phytoplankton abundance and DO dynamics.

Gut Microbiota-Targeted Diets Modulate Human Immune Status

This study examines how plant-based fiber and fermented food diets affect the gut microbiome and immune system in healthy adults over 17 weeks.

Characterization of an Agarophyton chilense oleoresin containing PPARγ natural ligands with insulin-sensitizing effects in a C57BL/6J mouse model of diet-induced obesity and antioxidant activity in Caenorhabditis elegans.

This study characterizes an oleoresin from Agarophyton chilense that activates PPARγ without adipocyte differentiation, improves insulin sensitivity in mice, and shows antioxidant activity in C. elegans.

Opportunities and challenges for improving a Colombian public research program in plant breeding and plant genetic resources lead by Agrosavia

The paper identifies opportunities and challenges for improving a Colombian plant breeding research program by analyzing survey data from researchers and proposing strategic principles for enhancement.

THE IMPACT OF THE HYDROXYMETHYLCYTOSINE EPIGENETIC SIGNATURE ON DNA STRUCTURE AND FUNCTION

This study investigates how 5-hydroxymethylation of DNA affects DNA structure and function, showing that hmC leads to more rigid DNA and alters MBD binding compared to mC.

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

This study uses single-molecule techniques to show that telomerase can extend and unfold parallel telomeric G-quadruplexes, revealing it acts as a resolvase.

A NKp80-based identification strategy reveals that CD56neg NK cells are not completely dysfunctional in health and disease.

This study identifies NKp80 as a reliable marker for CD56neg NK cells, showing they retain functional capacity in health and disease.

Long reads from Nanopore sequencing as a tool for animal microbiome studies

This study compares Illumina and Oxford Nanopore sequencing for ruminal microbiome analysis, finding that ONT provides more species-level classification due to longer reads but struggles with low-abundance archaeal and eukaryotic species.

Lymphocyte subpopulations and mast cells intestinal changes as indicators of inflammatory bowel disease in dogs

This study examines T and B lymphocyte populations and mast cells in dogs with IBD, finding increased numbers and degranulation in IBD samples.

Ubiquitination of the yeast receptor Atg32 modulates mitophagy

The paper shows that ubiquitination of Atg32 in yeast modulates mitophagy by affecting its stability and function during stationary phase and starvation.

Co-occurrence or dependence? Using spatial analyses to explore the interaction between palms and triatomines.

This study quantitatively analyzes the spatial relationship between Rhodnius triatomine species and palm species, finding strong associations in some cases but no improvement in predictive models when including palm presence.

Nanobody-antigen catch-bond reveals NK cell mechanosensitivity

This study measures antigen-antibody bond behavior under force using nanobodies and flow chamber assays, revealing catch bond properties and NK cell mechanosensitivity.

Drosophila larval brain neoplasms present tumour-type dependent genome instability

This study sequenced Drosophila tumours to assess genome instability, finding tumour-type dependent rates of SNPs and CNVs similar to human cancers.