Author

I. Cascone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. Ponzo· 2 shared A. Debesset· 1 shared A. Nicolas-Boluda· 1 shared A. Thiolat· 1 shared B. L. Salomon· 1 shared C. Houppe· 1 shared C. Kantari-Mimoun· 1 shared C. Pilon· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

M. Ponzo

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2 papers

Recent·Most cited

TNFR2 blockade promotes anti-tumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion

A. Debesset, C. Pilon, S. Meunier, O. Bonizec, W. Richer, A. Thiolat, C. Houppe, M. Ponzo, J. Magnan, P. Caudana, J. Tosello boari, S. Baulande, N. H. To, B. L. Salomon, E. Piaggio, , J. L. Cohen

This study shows that blocking TNFR2 reduces Treg activity and T cell exhaustion in PDAC, with improved efficacy when combined with CD40 agonists.

bioRxiv · Jan 22, 2024 · PreprintImmunology

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

A. Nicolas-Boluda, J. Vaquero, S. Barrin, C. Kantari-Mimoun, M. Ponzo, G. Renault, P. Deptula, K. Pogoda, R. Bucki, I. Cascone, J. Courty, L. Fouassier, F. Gazeau, E. Donnadieu

This study shows that inhibiting collagen crosslinking reduces tumor stiffness, enhances T cell migration, and improves anti-PD-1 treatment efficacy in mouse tumor models.

bioRxiv · May 19, 2020Cancer Biology