J. Tosello Boari

TNFR2 blockade promotes anti-tumoral immune response in PDAC by targeting activated Treg and reducing T cell exhaustion

This study shows that blocking TNFR2 reduces Treg activity and T cell exhaustion in PDAC, with improved efficacy when combined with CD40 agonists.

CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade

The paper identifies CD39+ CD4+ T cells in tumors with exhaustion and cytotoxic traits, showing their expansion with CTLA-4 blockade and association with better survival in breast cancer.

Interleukin-17 signaling influences CD8+ T cell immunity and tumor progression according to the IL-17 receptor subunit expression pattern in cancer cells

PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections

The paper identifies PD-L1hi plasmablasts that suppress T cell responses during acute parasite infections.

CD8+ T cell immunity is compromised by anti-CD20 treatment and rescued by IL-17A

This paper shows anti-CD20 treatment reduces CD8+ T cell immunity in a Trypanosoma cruzi infection model, and IL-17A can partially restore it.

IL-17RA-signaling modulates CD8+ T cell survival and exhaustion during Trypanosoma cruzi infection

This study shows that IL-17RA-signaling supports CD8+ T cell survival and function during Trypanosoma cruzi infection, with its absence leading to increased parasite load and reduced T cell responses.