Author

I. Chua

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Assay:flow cytometry· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. C. Goodnow· 2 shared D. Suan· 2 shared E. Masle-Farquhar· 2 shared G. Uzel· 2 shared J. H. Reed· 2 shared J. W. Leiding· 2 shared K. Heiskanen· 2 shared K. Preece· 2 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

C. C. Goodnow

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

E. Masle-Farquhar, K. J. L. Jackson, T. J. Peters, G. Al-Eryani, M. Singh, K. J. Payne, G. Rao, G. Apps, J. Kingham, C. J. Jara, K. Skvortsova, A. Swarbrick, C. Ma, D. Suan, G. Uzel, , C. C. Goodnow

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

bioRxiv · Feb 11, 2022 · PreprintImmunology

Overactive STAT3 drives accumulation of disease-associated CD21low B cells

E. Masle-Farquhar, T. J. Peters, K. J. Jackson, M. Singh, C. S. Ma, D. Suan, G. Uzel, I. Chua, J. W. Leiding, K. Heiskanen, K. Preece, L. Kainulainen, M. O Sullivan, M. A. Cooper, M. R. Seppänen, , C. C. Goodnow

This study shows that overactive STAT3 leads to the accumulation of disease-associated CD21low B cells in both humans and mice.

bioRxiv · Dec 20, 2021 · PreprintImmunology