G. Al-Eryani

Self-reactive B cells traverse a perfect storm of somatic mutagenesis to cause a virus-induced autoimmune disease

The paper traces the evolution of autoantibodies in HCV-CV patients, revealing convergent somatic mutations and compromised solubility in pathogenic B cells.

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers

The paper integrates single-cell RNA and protein data from breast cancer samples to identify novel lymphocyte phenotypes and their clinical relevance.

Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer

The paper shows that inhibiting lactate production in tumor cells suppresses PTEN/p53-deficient prostate cancer growth by activating macrophage phagocytosis.

STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells

This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy

This study uses DNA barcoding to track clonal evolution in breast cancer during metastasis and immunotherapy, finding ongoing immunoediting and identifying potential therapeutic targets.

Spatial Deconvolution of HER2-positive Breast Tumors Reveals Novel Intercellular Relationships

This study uses spatial transcriptomics to analyze HER2-positive breast tumors, revealing novel intercellular relationships and developing a model for tertiary lymphoid structures across tissues.

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.