T cell Egress via Lymphatic Vessels Limits the Intratumoral T cell Repertoire in Melanoma
M. M. Steele, I. D. Dryg, D. Murugan, J. Femel, H. du Bois, C. Hill, S. A. Leachman, Y. H. Chang, L. M. Coussens, A. W. Lund
The paper shows that T cell egress via lymphatic vessels limits intratumoral T cell diversity, and that CXCR4 inhibition enhances T cell retention and improves immunotherapy response.
bioRxiv · May 30, 2022 · PreprintImmunology