A targeted and tuneable DNA damage tool using CRISPR/Cas9.
I. Emmanouilidis, N. Fili, A. Cook, Y. Hari-Gupta, A. dos Santos, L. Wang, M. L. Martin-Fernandez, P. J. Ellis, C. P. Toseland
The paper develops a CRISPR/Cas9-based tool to induce targeted and tunable DNA double-strand breaks in human cells for studying repair mechanisms.
bioRxiv · Jan 23, 2021Cell Biology