Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
S. Makris, Y. Hari-Gupta, J. A. Cantoral-Rebordinos, V. G. Martinez, H. L. Horsnell, A. Benjamin, I. Cinti, D. Shewring, N. Nguyen, M. Jovancheva, C. M. de Winde, A. Denton, S. E. Acton
This study shows that Podoplanin deletion in fibroblastic reticular cells increases inflammatory signaling and disrupts stromal-immune crosstalk in lymph nodes.
bioRxiv · Dec 1, 2022Immunology
A. dos Santos, N. Fili, Y. Hari-Gupta, R. E. Gough, L. Wang, M. L. Martin-Fernandez, J. Arron, E. Wait, T. L. Chew, C. P. Toseland
This study investigates how binding partners regulate myosin VI unfolding and activation through biochemical and single-molecule analyses of splice isoforms.
Biochemical Journal · Jul 4, 2022Peer-reviewedBiophysics
A. dos Santos, D. E. Rollins, Y. Hari-Gupta, H. C. Reed, M. Du, S. Y. Z. Ru, K. Pidlisna, A. Stranger, F. Lorgat, I. Brown, K. Howland, J. Arron, L. Wang, P. J. Ellis, T. L. Chew, , C. P. Toseland
This study identifies NDP52's role in modulating RNA Polymerase II transcription by altering DNA conformation through direct dsDNA binding and interactions with chromatin regulators.
bioRxiv · Feb 1, 2022 · PreprintBiophysics
I. Emmanouilidis, N. Fili, A. Cook, Y. Hari-Gupta, A. dos Santos, L. Wang, M. L. Martin-Fernandez, P. J. Ellis, C. P. Toseland
The paper develops a CRISPR/Cas9-based tool to induce targeted and tunable DNA double-strand breaks in human cells for studying repair mechanisms.
bioRxiv · Jan 23, 2021Cell Biology
C. M. de Winde, S. L. George, A. Arp, A. C. Benjamin, E. Crosas-Molist, Y. Hari-Gupta, A. Carver, V. Imperatore, V. G. Martinez, V. Sanz-Moreno, S. E. Acton
This study shows podoplanin promotes amoeboid invasion and dedifferentiation in melanoma, suggesting it as a biomarker and therapeutic target.
bioRxiv · Jul 23, 2020Cancer Biology
A. dos Santos, N. Fili, D. Pearson, Y. Hari-Gupta, C. P. Toseland
This paper develops a high-throughput microplate reader assay for force-modulated biochemical and cell-based mechanobiology experiments.
bioRxiv · May 5, 2020Biophysics
Y. Hari-Gupta, N. Fili, A. dos Santos, A. W. Cook, R. E. Gough, H. C. W. Reed, L. Wang, J. Arron, T. Venit, E. Waite, A. Grosse-Berkenbusch, J. C. M. Gebhardt, P. Percipalle, T. L. Chew, M. L. Martin-Fernandez, C. P. Toseland
This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.
bioRxiv · Apr 21, 2020Cell Biology
A. Grosse-Berkenbusch, J. Hettich, T. Kuhn, N. Fili, A. W. Cook, Y. Hari-Gupta, A. Palmer, L. Streit, P. J. I. Ellis, C. Toseland, J. C. M. Gebhardt
This study shows nuclear myosin VI moves along actin filaments and facilitates transcription-dependent chromatin rearrangements.
bioRxiv · Apr 3, 2020 · PreprintCell Biology
N. Fili, Y. Hari-Gupta, B. Aston, A. dos Santos, R. Gough, B. Alamad, L. Wang, M. L. Martin-Fernandez, C. P. Toseland
The paper investigates how binding partners regulate myosin VI activity, showing that Dab2 loss increases nuclear myosin VI activity, promoting estrogen receptor-driven tumourgenesis.
bioRxiv · May 18, 2019 · PreprintCell Biology