C. P. Toseland

3D environment promotes persistent changes in lamin B1 distribution, the biomechanical signature of the nucleus, and adaptative survival and migratory functions.

The paper shows that 3D environments cause persistent nuclear changes, including lamin B1 distribution and mechanical behavior, affecting cell survival and migration.

Binding partners regulate unfolding of myosin VI to activate the molecular motor

This study investigates how binding partners regulate myosin VI unfolding and activation through biochemical and single-molecule analyses of splice isoforms.

Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription

This study identifies NDP52's role in modulating RNA Polymerase II transcription by altering DNA conformation through direct dsDNA binding and interactions with chromatin regulators.

A targeted and tuneable DNA damage tool using CRISPR/Cas9.

The paper develops a CRISPR/Cas9-based tool to induce targeted and tunable DNA double-strand breaks in human cells for studying repair mechanisms.

High throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays

This paper develops a high-throughput microplate reader assay for force-modulated biochemical and cell-based mechanobiology experiments.

Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

Binding partner regulation of Myosin VI: Loss of tumour-suppressor Dab2 leads to enhanced activity of nuclear myosin

The paper investigates how binding partners regulate myosin VI activity, showing that Dab2 loss increases nuclear myosin VI activity, promoting estrogen receptor-driven tumourgenesis.

The life of P.I. - Transitions to Independence in Academia

This report analyzes data from 365 UK-based principle investigators to identify challenges in transitioning to academic independence and suggests policy and support improvements.