Author

N. Fili

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Approach:microscopy & imaging analysis· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:imaging· 2 Assay:proteomics· 2

Frequent Co-Authors

Y. Hari-Gupta· 6 shared A. dos Santos· 5 shared C. P. Toseland· 5 shared L. Wang· 4 shared M. L. Martin-Fernandez· 4 shared A. Grosse-Berkenbusch· 2 shared A. W. Cook· 2 shared J. Arron· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersCell Biology

Y. Hari-Gupta

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Author profile →

6 papers

Recent·Most cited

Binding partners regulate unfolding of myosin VI to activate the molecular motor

A. dos Santos, N. Fili, Y. Hari-Gupta, R. E. Gough, L. Wang, M. L. Martin-Fernandez, J. Arron, E. Wait, T. L. Chew, C. P. Toseland

This study investigates how binding partners regulate myosin VI unfolding and activation through biochemical and single-molecule analyses of splice isoforms.

Biochemical Journal · Jul 4, 2022Peer-reviewedBiophysics

A targeted and tuneable DNA damage tool using CRISPR/Cas9.

I. Emmanouilidis, N. Fili, A. Cook, Y. Hari-Gupta, A. dos Santos, L. Wang, M. L. Martin-Fernandez, P. J. Ellis, C. P. Toseland

The paper develops a CRISPR/Cas9-based tool to induce targeted and tunable DNA double-strand breaks in human cells for studying repair mechanisms.

bioRxiv · Jan 23, 2021Cell Biology

High throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays

A. dos Santos, N. Fili, D. Pearson, Y. Hari-Gupta, C. P. Toseland

This paper develops a high-throughput microplate reader assay for force-modulated biochemical and cell-based mechanobiology experiments.

bioRxiv · May 5, 2020Biophysics

Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.

Y. Hari-Gupta, N. Fili, A. dos Santos, A. W. Cook, R. E. Gough, H. C. W. Reed, L. Wang, J. Arron, T. Venit, E. Waite, A. Grosse-Berkenbusch, J. C. M. Gebhardt, P. Percipalle, T. L. Chew, M. L. Martin-Fernandez, C. P. Toseland

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

bioRxiv · Apr 21, 2020Cell Biology

Myosin VI moves on nuclear actin filaments and supports long-range chromatin rearrangements

A. Grosse-Berkenbusch, J. Hettich, T. Kuhn, N. Fili, A. W. Cook, Y. Hari-Gupta, A. Palmer, L. Streit, P. J. I. Ellis, C. Toseland, J. C. M. Gebhardt

This study shows nuclear myosin VI moves along actin filaments and facilitates transcription-dependent chromatin rearrangements.

bioRxiv · Apr 3, 2020 · PreprintCell Biology

Binding partner regulation of Myosin VI: Loss of tumour-suppressor Dab2 leads to enhanced activity of nuclear myosin

N. Fili, Y. Hari-Gupta, B. Aston, A. dos Santos, R. Gough, B. Alamad, L. Wang, M. L. Martin-Fernandez, C. P. Toseland

The paper investigates how binding partners regulate myosin VI activity, showing that Dab2 loss increases nuclear myosin VI activity, promoting estrogen receptor-driven tumourgenesis.

bioRxiv · May 18, 2019 · PreprintCell Biology