Author

P. J. Ellis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. dos Santos· 2 shared C. P. Toseland· 2 shared L. Wang· 2 shared M. L. Martin-Fernandez· 2 shared Y. Hari-Gupta· 2 shared A. Cook· 1 shared A. L. B. Pyne· 1 shared A. Stranger· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

A. dos Santos

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Author profile →

3 papers

Recent·Most cited

The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice

E. E. K. Kopania, E. M. Watson, C. C. Rathje, B. M. Skinner, P. J. Ellis, E. L. Larson, J. M. Good

This study investigates how XY chromosome mismatch affects male fertility in hybrid house mice, finding that X chromosome overexpression in spermatids is linked to disrupted meiotic X-inactivation rather than XY gene copy number imbalance.

bioRxiv · Jul 19, 2022Evolutionary Biology

Autophagy receptor NDP52 alters DNA conformation to modulate RNA Polymerase II transcription

A. dos Santos, D. E. Rollins, Y. Hari-Gupta, H. C. Reed, M. Du, S. Y. Z. Ru, K. Pidlisna, A. Stranger, F. Lorgat, I. Brown, K. Howland, J. Arron, L. Wang, P. J. Ellis, T. L. Chew, , C. P. Toseland

This study identifies NDP52's role in modulating RNA Polymerase II transcription by altering DNA conformation through direct dsDNA binding and interactions with chromatin regulators.

bioRxiv · Feb 1, 2022 · PreprintBiophysics

A targeted and tuneable DNA damage tool using CRISPR/Cas9.

I. Emmanouilidis, N. Fili, A. Cook, Y. Hari-Gupta, A. dos Santos, L. Wang, M. L. Martin-Fernandez, P. J. Ellis, C. P. Toseland

The paper develops a CRISPR/Cas9-based tool to induce targeted and tunable DNA double-strand breaks in human cells for studying repair mechanisms.

bioRxiv · Jan 23, 2021Cell Biology