I. G. Macara

A Junction-Dependent Mechanism Drives Mammary Cell Intercalation for Ductal Elongation

This study identifies a junction-dependent mechanism for mammary cell intercalation driving ductal elongation through ZO-1 dynamics and cytoskeletal rearrangements.

Apoptotic Find-me Signals are an Essential Driver of Stem Cell Conversion To The Cardiac Lineage

This study shows that apoptotic signals drive stem cell conversion to the cardiac lineage through nucleotide-mediated paracrine signaling during mesoderm specification.

Genome-Wide CRISPR Screen Identifies Non-Canonical NF-κB Signaling as a Potent Regulator of Density-dependent Proliferation

The paper identifies non-canonical NF-κB signaling as a regulator of density-dependent proliferation through a CRISPR screen in murine mammary epithelial cells.

Non-autonomous induction of epithelial lineage infidelity and hyperplasia by DNA damage

The paper shows DNA damage induces hyperplasia and lineage infidelity in epithelial tissues through non-autonomous stromal signaling, promoting stemness and tissue disorganization.

Exocyst Dynamics During Vesicle Tethering and Fusion

This study investigates exocyst dynamics in mammalian cells, revealing tetrameric subcomplexes that dynamically associate with vesicles and plasma membrane.