Author
L. Fort
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2017-2024 · peak 1/yrCo-Author Collaboration Network
10 top collaborators · 36 mutual co-author links5 papers
Recent·Most cited
CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake
S. Nikolaou, A. Juin, J. A. Whitelaw, N. R. Paul, L. Fort, C. Nixon, H. J. Spence, S. Bryson, L. M. Machesky
The paper identifies CYRI-B as a mediator of macropinocytosis in pancreatic cancer, showing it suppresses metastasis by enabling lysophosphatidic acid receptor uptake.
bioRxiv · Nov 23, 2022Cancer Biology
Apoptotic Find-me Signals are an Essential Driver of Stem Cell Conversion To The Cardiac Lineage
L. Fort, V. Gama, I. G. Macara
This study shows that apoptotic signals drive stem cell conversion to the cardiac lineage through nucleotide-mediated paracrine signaling during mesoderm specification.
bioRxiv · Jun 21, 2021Cell Biology
CYRI-A regulates macropinocytic cup maturation and mediates integrin uptake, limiting invasive migration
A. H. Le, T. Yelland, N. Paul, L. Fort, S. Nikolaou, S. Ismail, L. Machesky
This study identifies CYRI-A as a regulator of macropinocytic cup maturation and integrin uptake, showing its role in limiting invasive migration.
bioRxiv · Dec 4, 2020Cell Biology
CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1
L. Fort, J. Batista, P. A. Thomason, H. J. Spence, J. Greaves, K. J. Martin, K. I. Anderson, P. Brown, S. Lilla, M. P. Neilson, P. Tafelmeyer, S. Zanivan, S. Ismail, N. C. O. Tomkinson, L. H. Chamberlain, , L. M. Machesky
This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.
bioRxiv · Nov 29, 2017Cell Biology