Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22
D. Schnepf, P. Hernandez, T. Mahlakoiv, S. Crotta, M. E. Sullender, S. T. Peterson, A. Ohnemus, C. Michiels, I. Gentle, L. Dumoutier, C. A. Reis, A. Diefenbach, A. Wack, M. T. Baldridge, P. Staeheli
This study shows that antibiotic-treated mice are more susceptible to rotavirus due to reduced IL-22 expression, which normally inhibits viral replication through mechanisms independent of IFN signaling.
bioRxiv · Feb 18, 2021Immunology